王奇教授-广州中医药大学科技创新中心

王奇 WANG QI 教授（二级）

所属学院（所）：科技创新中心、临床药理研究所

导师类别： 博士生导师、硕士生导师

科研方向： 老年脑病的临床与实验研究

博士招生学院： 科技创新中心、临床药理研究所

硕士招生学院： 科技创新中心、、临床药理研究所

个人简述

1963年7月出生，安徽庐江人，汉族，中共党员，临床药理研究所所长，二级教授，博士生导师。

学科领域

科学学位：中医内科学

教育背景

1980年至1985年安徽中医学院中医专业学士，获学士学位。

1985年至1988年中山医科大学病理生理学专业研究生，获硕士学位。

工作经历

1988年7月至今，广州中医药大学临床药理研究所，其间，1995年12月破格晋升为副研究员。2000年破格晋升为研究员、教授。2015年晋升为二级教授。

2000年1月广州中医药大学临床药理研究所副所长，2006年8月广州中医药大学临床药理研究所所长。

1995年8年赴美国加州大学圣地亚哥校园进行老年性痴呆合作研究，1999年10月参加新加坡国家医学委员会“临床试验统计分析培训班”培训。

学术兼职

中国阿尔茨海默病防治协会常务理事

中国药理学会中药与天然药物药理专业委员会常委

中国药理学会补益药药理专业委员会常委

中国药理学会老年性痴呆专业委员会常委

中国药理学会生化与分子药理专业委员会常委

中国中西医结合学会临床药理与毒理专业委员会常委

中国睡眠研究会中医睡眠医学专业委员会常委

世界中医药学会联合会临床疗效评价专业委员会常务理事

中国药学会老年药学专业委员会常委

中国民族医药学会药理与毒理学分会常务理事

中国老年学学会老年医学委员会认知障碍专家委员会委员

主要荣誉

1.“补肾法为主治疗Alzheimer病的研究”广东省科学技术二等奖，2002年

2.“建立中医药临床疗效系统评价体系关键技术的研究”广东省科学技术三等奖，2002年

3.“国家新药（中药）临床试验研究中心建设及中药临床试验关键技术研究”中华中医药学会科学技术二等奖，2006年

4.“当代循证医学方法在中医学中的应用研究”中国中西医结合学会科学技术三等奖，2008年

5.中华全国青联、中国中医药学会首届“中国百名杰出青年中医提名奖”，1996年

6.卫生部、国家中医药管理局、总后卫生部第二届“全国中青年医学科技之星”荣誉称号，1996年

7.广东省高等学校“千百十工程”省级培养对象，2001年～2005年

主要论著：

1.《中西医结合临床研究方法学》（副主编，科学出版社）

2．《中药临床试验》（副主编，广东人民出版社）

3．《中药新药研制开发技术与方法》（副主编，上海科技出版社）

4．《高等药理学》（编委，科学出版社，待出版）

承担科研课题：

1.国家自然科学基金面上项目“基于VEGF-C/VEGFR-3信号通路探讨当归芍药散经脑膜淋巴管引流促进痴呆动物Aβ清除的机制研究”（82274616），2023.01-2026.12，52万元，主持

2.国家自然科学基金面上项目“基于肠道CYP3A酶代谢途径探讨补肾益智方提高蛇床子素生物利用度治疗老年性痴呆的机制研究”（81973918），2020.01-2023.12，52万元，主持

3.国家自然科学基金面上项目“藁本内酯通过调节脑血管内皮细胞GLUT1改善痴呆动物血脑屏障Aβ转运及清除的机制研究”（81673627），2017.01-2020.12，52万元，主持

4.国家自然科学基金面上项目“基于BAP理论从细胞内Aβ清除和生物利用度角度探讨当归芍药散对阿尔茨海默病的作用机制研究”（81473740），2015.01-2018.12，73万元，主持

5.国家自然科学基金面上项目“当归芍药散改善痴呆动物脑微血管内皮细胞功能障碍及调节血脑屏障Aβ转运机制的研究”（81273817），2013.01-2016.12，72万元，主持

6.国家自然科学基金面上项目“血瘀证血管内皮细胞内分泌功能的实验研究”（39270817），1993.01-1995.12，3.9万元，主持

7.广东省科技计划国际合作项目“醒脑开窍”代表方剂配伍规律的物质基础及作用机制研究（2020A0505100052），2020.09-2022.12，50万元，主持

8.广东省基础与应用基础研究基金企业联合基金“不同剂型的当归芍药散成分差异分析及其改善老年性痴呆学习记忆能力的药效比较研究”（2022A1515220121）， 2022.11-2025.10，15万元，主持

9.广东省普通高校“中医脑病研究重点实验室”（2019KSYS005），2020.01-2022.12，50万元，主持

10.广东省重大科技专项“补肾益智方有效部位治疗老年性痴呆的新药研究”（2012A080202017），2013.01-2017.12，120万元，主持

11.广州市科技局项目“广州市中医药防治脑病研究重点实验室”（201805010005），2018.1-2020.12，200万元，主持

12.教育部高等学校博士学科点专项科研基金“石菖蒲组分配伍对转基因痴呆小鼠学习记忆和神经元突触可塑性影响的研究”（20114425110007），2012.1—2014.12，12万元，主持

13.教育部高等学校博士学科点专项科研基金“补肾益智方活性成分调控ApoE介导的AD细胞模型Aβ清除和p38MAPK信号通路机制研究”（20134425110003），2014.1—2016.12，12万元，主持

14.广东省科技计划重点项目“补肾益智胶囊治疗老年性痴呆的新药开发”，编号：2010A030100009，2011.1-2013.12，40万元，主持

15.国家科技部，国家科技重大专项“重大新药创制”课题“中药新药临床评价技术平台研究”，编号：2008ZX09312-021，2008.10-2010.12，667万元，排名第2。

主要论文（第一作者或者通讯作者）：

主要SCI论文：

2024年

1. Xiaoling Fang; Dishu Zhou; Xinyue Wang; Yujie Ma; Guangcheng Zhong; Shangwen Jing; Shuiqing Huang; Qi Wang（王奇，通讯作者）; Exosomes: A Cellular Communication Medium That Has Multiple Effects On Brain Diseases, Molecular Neurobiology , 2024

2. Liu XQ, Hu T, Wu GL, Qiao LJ, Cai YF*, Wang Q*（王奇, 通讯作者）, Zhang SJ*. Tanshinone IIA, the key compound in Salvia miltiorrhiza, improves cognitive impairment by upregulating Aβ-degrading enzymes in APP/PS1 mice. Int J Biol Macromol. 2024 Jan;254(Pt 2):127923. doi: 10.1016/j.ijbiomac.2023.127923. Epub 2023 Nov 7.

2023年

1. Chen G, Han M, Chen Y, Lei Y, Li M, Wang L, Wang C, Hu Y, Niu J, Yang C, Mo Y, Wang Q*（王奇, 通讯作者）, Yang L*, Chang X*. Danggui-Shaoyao-San Promotes Amyloid-β Clearance through Regulating Microglia Polarization via Trem2 in BV2 Cells. J Integr Neurosci. 2023 May 15;22(3):72. doi: 10.31083/j.jin2203072.

2. Tan HY, Wan C, Wu GL, Qiao LJ, Cai YF*, Wang Q*（王奇, 通讯作者）, Zhang SJ*. Taohong siwu decoction ameliorates cognitive dysfunction through SIRT6/ER stress pathway in Alzheimer's disease. J Ethnopharmacol. 2023 Oct 5;314:116580. doi: 10.1016/j.jep.2023.116580. Epub 2023 May 2.

3. Su S, Chen G, Gao M, Zhong G, Zhang Z, Wei D, Luo X, Wang Q*（王奇, 通讯作者）. Kai-Xin-San protects against mitochondrial dysfunction in Alzheimer's disease through SIRT3/NLRP3 pathway. Chin Med. 2023 Mar 14;18(1):26. doi: 10.1186/s13020-023-00722-y.

4. Chen H, Liu C, Li M, Zhang Y, Wang Z, Jiang Q, Wang J, Wang Q*（王奇, 通讯作者）, Zhuo Y*. Ferulic acid prevents Diosbulbin B-induced liver injury by inhibiting covalent modifications on proteins. Drug Metab Pharmacokinet. 2023 Jun;50:100507. doi: 10.1016/j.dmpk.2023.100507. Epub 2023 Mar 30.

5. Xiao Q, Liu H, Yang C, Chen Y, Huang Y, Xiao X, Pan Y, He J, Du Q, Wang Q*（王奇, 通讯作者）, Zhang Y*. Bushen-Yizhi formula exerts neuroprotective effect via inhibiting excessive mitophagy in rats with chronic cerebral hypoperfusion. J Ethnopharmacol. 2023 Jun 28;310:116326. doi: 10.1016/j.jep.2023.116326. Epub 2023 Mar 9.

6. Chen Y, Cui T, Xiao S, Li T, Zhong Y, Tang K, Guo J, Huang S, Chen J, Li J, Wang Q*（王奇, 通讯作者）, Huang J*, Pan H*, Gao Y*. Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling. iScience. 2023 Mar 2;26(4):106318. doi: 10.1016/j.isci.2023.106318.

7. Wang J, Shi J, Xiao Y, Chen G, Yang C, Duan L, Zhao W, Wang Q*（王奇, 通讯作者）. Fo-Shou-San Ameliorates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment in Mice by Regulating NRF2/HO-1 Pathway Against Ferroptosis. J Integr Neurosci. 2023 Feb 16;22(2):41. doi: 10.31083/j.jin2202041.

8. Liu C, Chen H, Zhang Y, Li M, Jiang Q, Wang Z, Yu L, Wang Q*（王奇, 通讯作者）, Pan H*, Zhuo Y*. Combination of chemical profiling and network pharmacology analysis to investigate the potential mechanism of Li-Zhong-Xiao-Pi granules in the treatment of gastric precancerous lesions. Biomed Chromatogr. 2023 Apr;37(4):e5589. doi: 10.1002/bmc.5589. Epub 2023 Feb 7.

9. Liu J, Yu W, Ma C, Li T, Liang Y, Su S, Zhong G, Xie Z, Wu Q, Chen J, Wang Q*（王奇, 通讯作者）. Network Pharmacology and Mechanism Studies of the Protective Effect of Ginseng against Alzheimer's Disease Based on Aβ Pathogenesis. Planta Med. 2023 Aug;89(10):990-1000. doi: 10.1055/a-2014-6061. Epub 2023 Jan 17.

10. Zhong G, Wang X, Li J, Xie Z, Wu Q, Chen J, Wang Y, Chen Z, Cao X, Li T, Liu J*, Wang Q*（王奇, 通讯作者）. Insights Into the Role of Copper in Neurodegenerative Diseases and the Therapeutic Potential of Natural Compounds. Curr Neuropharmacol. 2023 Nov 15. doi: 10.2174/1570159X22666231103085859. Epub ahead of print.

11. He H, Li N, Fan Y, Huang Q, Song J, Lv L, Liu F, Wang L, Wang Q*（王奇, 通讯作者）, Gu J*. Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities. Chin J Nat Med. 2023 Nov;21(11):852-858. doi: 10.1016/S1875-5364(23)60480-7.

12. Luo Y, Li D, Liao Y, Cai C, Wu Q, Ke H, Liu X, Li H, Hong H, Xu Y, Wang Q*（王奇, 通讯作者）, Fang J*, Fang S*. Corrigendum: Systems pharmacology approach to investigate the mechanism of Kai-Xin-San in Alzheimer's disease. Front Pharmacol. 2023 Oct 6;14:1239060. doi: 10.3389/fphar.2023.1239060. Erratum for: Front Pharmacol. 2020 Apr 03;11:381.

13. Xiao X, Hu H, Zhong Y, Chen Y, Tang K, Pan Z, Huang J, Yang X*, Wang Q*（王奇, 通讯作者）, Gao Y*. Correction: Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity. Mol Med. 2023 Sep 19;29(1):128. doi: 10.1186/s10020-023-00723-5. Erratum for: Mol Med. 2023 Aug 15;29(1):108.

14. Liu J, Zuo X, Huang M, Fang J, Li W, Shi Q, Wang Q*（王奇, 通讯作者）, Liang Y*. Multifunctional Gomisin B enhances cognitive function in APP/PS1 transgenic mice by regulating Aβ clearance and neuronal apoptosis. Biomed Pharmacother. 2023 Oct;166:115423. doi: 10.1016/j.biopha.2023.115423. Epub 2023 Sep 8.

15. Liu J, Li T, Zhong G, Pan Y, Gao M, Su S, Liang Y, Ma C, Liu Y, Wang Q*（王奇, 通讯作者）, Shi Q*. Exploring the therapeutic potential of natural compounds for Alzheimer's disease: Mechanisms of action and pharmacological properties. Biomed Pharmacother. 2023 Oct;166:115406. doi: 10.1016/j.biopha.2023.115406. Epub 2023 Sep 4.

16. Xiao X, Hu H, Zhong Y, Chen Y, Tang K, Pan Z, Huang J, Yang X*, Wang Q*（王奇, 通讯作者）, Gao Y*. Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity. Mol Med. 2023 Aug 15;29(1):108. doi: 10.1186/s10020-023-00676-9. Erratum in: Mol Med. 2023 Sep 19;29(1):128.

17. Liu J, Wu Q, Wu Q, Zhong G, Liang Y, Gu Y, Hu Y, Wang W, Hao N, Fang S, Li W, Pan H, Wang Q*（王奇, 通讯作者）, Fang J*. Modulating endoplasmic reticulum stress in APP/PS1 mice by Gomisin B and Osthole in Bushen-Yizhi formula: Synergistic effects and therapeutic implications for Alzheimer's disease. Phytomedicine. 2023 Oct;119:155023. doi: 10.1016/j.phymed.2023.155023. Epub 2023 Aug 12.

18. Zhuo Y, Chen H, Liu C, Zhang Y, Fang J, Li M, Wang Z, Jiang Q, Yu L, Pan H*, Wang Q*（王奇, 通讯作者）. Covalent Modification of Proteins by Osthole Reactive Metabolites using Proteomic Approaches. Curr Drug Metab. 2023;24(8):611-620. doi: 10.2174/1389200224666230727123006.

19. Wu F, Huang M, Zuo X, Xie R, Liu J, Ke J, Li W, Wang Q*（王奇, 通讯作者）, Liang Y*. Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice. Front Pharmacol. 2023 Jul 13;14:1224856. doi: 10.3389/fphar.2023.1224856.

20. Jing S, Wang X, Zhang Z, Cao D, Huang K, Wang Y, Liu Z, Su S, Wang Q*（王奇, 通讯作者）. Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice. Metab Brain Dis. 2023 Oct;38(7):2443-2456. doi: 10.1007/s11011-023-01250-2. Epub 2023 Jun 29.

2022年

1. Chen J, Pan Y, Liu Q, Li G, Chen G, Li W, Zhao W*, Wang Q*（王奇, 通讯作者）. The Interplay between Meningeal Lymphatic Vessels and Neuroinflammation in Neurodegenerative Diseases. Curr Neuropharmacol. 2022 Nov 15. doi: 10.2174/1570159X21666221115150253. Epub ahead of print.

2. Bai G, Jing S, Cao H, Qiao Y, Chen G, Duan L, Yang Y, Li M, Li W, Chang X, Yang C, Wang Q*（王奇, 通讯作者）. Kai-Xin-San Protects Depression Mice Against CORT-Induced Neuronal Injury by Inhibiting Microglia Activation and Oxidative Stress. Evid Based Complement Alternat Med. 2022 Oct 19;2022:5845800. doi: 10.1155/2022/5845800.

3. Zhong Y, Chen Y, Pan Z, Tang K, Zhong G, Guo J, Cui T, Li T, Duan S, Yang X*, Gao Y*, Wang Q*（王奇, 通讯作者）, Zhang D*. Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress. Front Pharmacol. 2022 Oct 7;13:1027731. doi: 10.3389/fphar.2022.1027731.

4. Lv LX, Wu Y, He HX, Li NP, Zhao W, Fan YQ, Wei X, Su JC*, Wang Q*（王奇, 通讯作者）, Gu JH*. Acronyrones A-C, unusual prenylated acetophenones from Acronychia pedunculata. Fitoterapia. 2022 Nov;163:105303. doi: 10.1016/j.fitote.2022.105303. Epub 2022 Sep 22.

5. Zhu Y, Wang A, Zhang S, Kim J, Xia J, Zhang F, Wang D, Wang Q*（王奇, 通讯作者）, Wang J*. Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy by dual targeting of the tumor microenvironment and cancer cells. Journal of Advanced Research. 2023 Jul;49:159-173. doi: 10.1016/j.jare.2022.09.007. Epub 2022 Sep 24.

6. Jing S, Lu Y, Zhang J, Ren Y, Mo Y, Liu D, Duan L, Yuan Z, Wang C*, Wang Q*（王奇, 通讯作者）. Levistilide a Induces Ferroptosis by Activating the Nrf2/HO-1 Signaling Pathway in Breast Cancer Cells. Drug Des Devel Ther. 2022 Sep 7;16:2981-2993. doi: 10.2147/DDDT.S374328.

7. Chen N, Wang XC, Fan LL, Zhu YH, Wang Q*（王奇, 通讯作者）, Chen YB*. Berberine Ameliorates Lipopolysaccharide-Induced Cognitive Impairment Through SIRT1/NRF2/NF-κB Signaling Pathway in C57BL/6J Mice. Rejuvenation Res. 2022 Oct;25(5):233-242. doi: 10.1089/rej.2022.0023. Epub 2022 Sep 26.

8. Zhao Y, Liu N, Liu P, Fan T, Ma R, Hong H, Chen X, Xie Z, Zhang H*, Wang Q*（王奇, 通讯作者）, Chen T*. Robust boron nanoplatform provokes potent tumoricidal activities via inhibiting heat shock protein. Asian J Pharm Sci. 2022 Aug;17(5):728-740. doi: 10.1016/j.ajps.2022.06.003. Epub 2022 Jul 29.

9. Qin B, Zeng Z, Xu J, Shangwen J, Ye ZJ, Wang S, Wu Y, Peng G, Wang Q*（王奇, 通讯作者）, Gu W*, Tang Y*. Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin. BMC Cancer. 2022 Jun 18;22(1):671. doi: 10.1186/s12885-022-09684-0.

10. Liu P, Zhou X, Zhang H, Wang R, Wu X, Jian W, Li W, Yuan D*, Wang Q*（王奇, 通讯作者）, Zhao W*. Danggui-Shaoyao-San Attenuates Cognitive Impairment via the Microbiota-Gut-Brain Axis With Regulation of Lipid Metabolism in Scopolamine-Induced Amnesia. Front Immunol. 2022 May 19;13:796542. doi: 10.3389/fimmu.2022.796542.

11. Peng D, Qiao HZ, Tan HY, Wang YX, Luo D, Qiao LJ, Cai YF, Zhang SJ*, Wang Q*（王奇, 通讯作者）, Guan L*. Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat. Metab Brain Dis. 2022 Jun;37(5):1401-1414. doi: 10.1007/s11011-022-00947-0. Epub 2022 Apr 14.

12. Wu M, Zhai Y, Liang X, Chen W, Lin R, Ma L, Huang Y, Zhao D, Liang Y, Zhao W, Fang J, Fang S, Chen Y, Wang Q*（王奇, 通讯作者）, Li W*. Connecting the Dots Between Hypercholesterolemia and Alzheimer's Disease: A Potential Mechanism Based on 27-Hydroxycholesterol. Front Neurosci. 2022 Apr 7;16:842814. doi: 10.3389/fnins.2022.842814.

13. Song L, Wu Q, Fu X, Wang W, Dai Z, Gu Y, Zhuo Y, Fang S, Zhao W, Wang X, Wang Q*（王奇, 通讯作者）, Fang J*. In Silico Identification and Mechanism Exploration of Active Ingredients against Stroke from An-Gong-Niu-Huang-Wan (AGNHW) Formula. Oxid Med Cell Longev. 2022 Apr 5;2022:5218993. doi: 10.1155/2022/5218993.

14. Peng D, Xia Q, Guan L, Li HY, Qiao LJ, Chen YB, Cai YF*, Wang Q*（王奇, 通讯作者）, Zhang SJ*. Carnosine Improves Cognitive Impairment Through Promoting SIRT6 Expression and Inhibiting Endoplasmic Reticulum Stress in a Diabetic Encephalopathy Model. Rejuvenation Res. 2022 Apr;25(2):79-88. doi: 10.1089/rej.2022.0002.

2021年

1. Zeng H, Qiao Y, Luo X, Chen X, Wang Z, Pan H*, Wang Q*（王奇, 通讯作者）, Zheng GQ*. History and Development of TCM Case Report in a Real-World Setting. Evid Based Complement Alternat Med. 2021 Dec 29;2021:7402979. doi: 10.1155/2021/7402979.

2. Li H, Peng D, Zhang SJ, Zhang Y, Wang Q*（王奇, 通讯作者）, Guan L*. Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model. Mol Med Rep. 2021 Nov;24(5):791. doi: 10.3892/mmr.2021.12431. Epub 2021 Sep 13.

3. Bai G, Qiao Y, Lo PC, Song L, Yang Y, Duan L, Wei S, Li M, Huang S, Zhang B*, Wang Q*（王奇, 通讯作者）, Yang C*. Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation. J Ethnopharmacol. 2022 Jan 30;283:114717. doi: 10.1016/j.jep.2021.114717. Epub 2021 Oct 7.

4. Chen J, Liu J, Huang Y, Li R, Ma C, Zhang B, Wu F, Yu W, Zuo X, Liang Y*, Wang Q*（王奇, 通讯作者）. Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition. Drug Metab Rev. 2021 Nov;53(4):491-507. doi: 10.1080/03602532.2021.1917598. Epub 2021 Apr 27.

5. Liu JM, Chen JM, Lin MJ, Wu FC, Ma CR, Zuo X, Yu WQ, Huang MJ, Fang JS, Li WR, Wang Q*（王奇, 通讯作者）, Liang Y*. Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma. J Ethnopharmacol. 2022 Jan 10;282:114643. doi: 10.1016/j.jep.2021.114643. Epub 2021 Sep 14.

6. Duan L, Qiu W, Bai G, Qiao Y, Su S, Lo PC, Lu Y, Xu G, Wang Q*（王奇, 通讯作者）, Li M*, Mo Y*. Metabolomics Analysis on Mice With Depression Ameliorated by Acupoint Catgut Embedding. Front Psychiatry. 2021 Aug 3;12:703516. doi: 10.3389/fpsyt.2021.703516.

7. Chen XH, Zhao YY, Wang Q*（王奇, 通讯作者）, Li ZL, Li FX, Tan HY, Huang YY. Chemical constituents from the stems of Acanthopanax senticosus with their cytotoxic activities. J Asian Nat Prod Res. 2022 Jul;24(7):673-678. doi: 10.1080/10286020.2021.1951713. Epub 2021 Jul 26.

8. Yang C, Mo YS, Chen HF, Huang YH, Li SL, Wang H, Huang SQ, Chang X, Du Q*, Wang Q*（王奇, 通讯作者）. The effects of Danggui-Shaoyao-San on neuronal degeneration and amyloidosis in mouse and its molecular mechanism for the treatment of Alzheimer's disease. J Integr Neurosci. 2021 Jun 30;20(2):255-264. doi: 10.31083/j.jin2002025.

9. Wei SF, He DH, Zhang SB, Lu Y, Ye X, Fan XZ, Wang H, Wang Q*（王奇, 通讯作者）, Liu YQ*. Identification of pseudolaric acid B as a novel Hedgehog pathway inhibitor in medulloblastoma. Biochem Pharmacol. 2021 Aug;190:114593. doi: 10.1016/j.bcp.2021.114593. Epub 2021 May 6.

10. Luo Y, Chen H, Tsoi B, Wang Q*（王奇, 通讯作者）, Shen J*. Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases. Front Pharmacol. 2021 Apr 15;12:653795. doi: 10.3389/fphar.2021.653795.

11. Duan L, Zhang Y, Yang Y, Su S, Zhou L, Lo PC, Cai J, Qiao Y, Li M, Huang S, Wang H, Mo Y*, Wang Q*（王奇, 通讯作者）. Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage. Front Pharmacol. 2021 Mar 19;12:629379. doi: 10.3389/fphar.2021.629379.

12. Ji X , Mo Y , Li H , Zhao W , Zhong A , Li S , Wang Q*（王奇, 通讯作者） , Duan X* , Xiao J* . Gender-dependent reproductive toxicity of copper metal-organic frameworks and attenuation by surface modification. Nanoscale. 2021 Apr 21;13(15):7389-7402. doi: 10.1039/d1nr01008e. Epub 2021 Apr 13.

13. Xiong S, Luo J, Wang Q, Li Z, Li J, Liu Q, Gao L, Fang S, Li Y, Pan H, Wang H, Zhang Y, Wang Q*（王奇, 通讯作者）, Chen X*, Chen T*. Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease. Biomater Sci. 2021 Mar 10;9(5):1705-1715. doi: 10.1039/d0bm01765e.

14. Sun T, Xu Y, Xu Z, Cao B, Zhang Z, Wang Q*（王奇, 通讯作者）, Kong Y*, Mao X*. Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis. Cell Commun Signal. 2021 Feb 24;19(1):24. doi: 10.1186/s12964-020-00676-w.

15. Mo Y , Duan L , Yang Y , Liu W , Zhang Y , Zhou L , Su S , Lo PC , Cai J , Gao L , Liu Q , Chen X , Yang C* , Wang Q*（王奇, 通讯作者） , Chen T* . Nanoparticles improved resveratrol brain delivery and its therapeutic efficacy against intracerebral hemorrhage. Nanoscale. 2021 Feb 14;13(6):3827-3840. doi: 10.1039/d0nr06249a. Epub 2021 Feb 10.

2020年

1. Hong H#, Mo Y#, Li D#, Xu Z, Liao Y, Yin P, Liu X, Xia Y, Fang J*, Wang Q*（王奇, 通讯作者） and Fang S*. Aberrant Expression Profiles of lncRNAs and Their Associated Nearby Coding Genes in the Hippocampus of the SAMP8 Mouse Model with AD. Mol Ther Nucleic Acids. 2020; 20:140-154.

2. Tong Sun, Yujia Xu, Zhuan Xu, Biyin Cao, Zubin Zhang, Qi Wang *（王奇, 通讯作者）, Yan Kong*, Xinliang Mao*, Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice, Cell Communication and Signaling, 2020 Apr 8, 12(7):6401-6414. doi: 10.21203/rs.3.rs-26509/v1

3. Ting-Ting Xu, Han Li, Zhao Dai ,George K. Lau, Ben-Yue Li, Wen-Li Zhu, Xiao-Qi Liu, Hao-Fei Liu, Wei-Wu Cai, Shui-Qing Huang, Qi Wang*（王奇, 通讯作者）, Shi-Jie Zhang*, Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice, Aging, 2020 Apr 8, 12(7):6401-6414. doi:10.18632/aging.103035

4. Haobin Cai, Tiantian Cai, Haotao Zheng, Lijin Liu, Liuchang Zhou, Xile Pang, Qinkai Zhan, Yijie Wang, Cong Yang, Zhouke Guo, Huafeng Pan, Qi Wang*（王奇, 通讯作者）, The Neuroprotective Effects of Danggui-Shaoyao San on Vascular Cognitive Impairment: Involvement of the Role of the Low-Density Lipoprotein Receptor-Related Protein, Rejuvenation Research, 2020 Aug 3, doi: 10.1089/rej.2019.2182

5. Yunxia Luo, Dongli Li, Yanfang Liao, Chuipu Cai, Qihui Wu, Hanzhong Ke, Xinning Liu, Huilin Li, Honghai Hong, Yumin Xu, Qi Wang*（王奇, 通讯作者）, Jiansong Fang* and Shuhuan Fang*, Systems Pharmacology Approach to Investigate the Mechanism of Kai-Xin-San in Alzheimer's Disease, Frontiers in Pharmacology, 2020 Apr 3, 11:381. doi: 10.3389/fphar.2020.00381

6. Zhao Dai, Xin-Yi Lu, Wen-Li Zhu, Xiao-Qi Liu, Ben-Yue Li, Lei Song, Hao-Fei Liu, Wei-Wu Cai, Ya-Xiang Deng, Ting-Ting Xu, Qi Wang*（王奇, 通讯作者）, Shi-Jie Zhang*, Carnosine ameliorates age-related dementia via improving mitochondrial dysfunction in SAMP8 mice, Food & Function, 2020 Mar 1, 11(3):2489-2497. doi: 10.1039/c9fo02453k

7. Wen-Li Zhu, Jia-Yi Zheng, Wei-Wu Cai, Zhao Dai, Ben-Yue Li, Ting-Ting Xu, Hao-Fei Liu, Xiao-Qi Liu, Su-Fen Wei, Yi Luo, Hong Wang, Hua-Feng Pan, Qi Wang*（王奇, 通讯作者）, Shi-Jie Zhang*, Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice, Aging, 2020 Feb 16, 12(4):3175-3189.

doi: 10.18632/aging.102793

8. Xiao-Qi Liu, Ya-Xiang Deng, Zhao Dai, Tian Hu, Wei-Wu Cai, Hao-Fei Liu, Han Li, Wen-Li Zhu, Ben-Yue Li, Qi Wang*（王奇, 通讯作者）, Shi-Jie Zhang*, Sodium tanshinone IIA sulfonate protects against Aβ 1-42-induced cellular toxicity by modulating Aβ-degrading enzymes in HT22 cells, International Journal of Biological Macromolecules, 2020 May 15, 151:47-55. doi:10.1016/j.ijbiomac.2020.02.040

9. Yu Mei, Zihao Wang, Yifan Zhang, Ting Wan, Jincheng Xue, Wei He, Yi Luo, Yijun Xu, Xue Bai, Qi Wang*（王奇, 通讯作者）, Yujie Huang*, FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Ameliorates DSS-Induced Colitis Against Oxidative Stress by Activating Nrf2/HO-1 Pathway, Frontiers in Immunology(IF:4.868), 2020 Jan 8, 10:2969. doi: 10.3389/fimmu.2019.02969

10. Wen-Xuan Jian, Zhao Zhang, Jia-Hong Zhan, Shi-Feng Chu, Ye Peng, Ming Zhao, Qi Wang, Nai-Hong Chen, Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation, Acta Pharmacologica Sinica, 2020 May, 41(5):588-598. doi: 10.1038/s41401-019-0334-5

2019年

1. Weiping Liu, Shaoling Li, Ziling Qu, Yi Luo, Ruifeng Chen, Sufen Wei, Xin Yang, Qi Wang* （王奇, 通讯作者）, Betulinic acid induces autophagy-mediated apoptosis through suppression of the PI3K/AKT/mTOR signaling pathway and inhibits hepatocellular carcinoma, American journal of translational research, 2019 Nov 15, 11(11):6952-6964

2. Chaoyin Wu, Benyue Li, Yi Zhang, Tingting Chen, Chuangrong Chen, Wei Jiang, Qi Wang* （王奇, 通讯作者）, Tongkai Chen*, Intranasal delivery of paeoniflorin nanocrystals for brain targeting, Asian Journal of Pharmaceutical Sciences, 2019 Nov 26, 15(3):326-335. doi: 10.1016/j.ajps.2019.11.002.

3. Hui-Lin Wang, Hua Zeng, Meng-Bei Xu, Xiao-Li Zhou, Pei-Qing Rong, Ting-Yu Jin, Qi Wang* （王奇, 通讯作者）and Guo-Qing Zheng*, Efficacy and Safety of Chinese Herbal Medicine for Primary Intracerebral Hemorrhage: A Systematic Review of Randomized Controlled Trials, Frontiers in Pharmacology, 2019 Oct 10, 10:1139. doi: 10.3389/fphar.2019.01139

4. Yingying Wang , Xiuyun Song , Dandan Liu , Yu-xia Lou , Piao Luo , Tianbi Zhu, Qi Wang **（王奇, 通讯作者）,Naihong Chen *, IMM-H004 reduced okadaic acid-induced neurotoxicity by inhibiting Tau pathology in vitro and in vivo, NeuroToxicology, 2019 Sep 21,11:381. doi:10.1016/j.neuro.2019.09.012

5. Xinchen Wang , Yumin Xu , Chenliang Chu, Hongying Li, Jia Mi, Zehuai Wen, Shijie Zhang*, Qi Wang*（王奇, 通讯作者）and Shijian Quan*,Effect of safflower yellow on early type II diabetic nephropathy: a systematic review and meta-analysis of randomized controlled trials, Journal of pediatric endocrinology & metabolism, 2019 Jun 11,32(7): 653–665. doi: 10.1515/jpem-2018-0425

11. Yi Luo, Yu Feng, Lei Song, GanQing He, Sha Li, ShaSha Bai, YuJie Huang, SiYing Li, Mohammed M. Almutairi, HongLian Shi, Qi Wang*（王奇，通讯作者） and Ming Hong*，A network pharmacology‑based study on the anti‑hepatoma effect of Radix Salviae Miltiorrhizae, Chin Med, 2019 Aug 6, 14:27.doi:10.1186/s13020-019-0249-6

12. Cong Yang, Yousheng Mo, Erjin Xu, Huihong Wen, Renrong Wei, Shaoling Li, Jiayi Zheng, Weirong Li, Baoluu Le, Yonggen Chen, Huafeng Pan, Shuiqing Huang, Shengqiang Wang⁎, Qi Wang*（王奇，通讯作者）, Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinson's disease mouse model，August 2019，International immunopharmacology，DOI: 10.1016/j.intimp.2019.05.036

13. LEI SONG#, YI LUO#, XINYUE WANG#, MOHAMMED M. ALMUTAIRI, HUAFENG PAN, WEIRONG LI, YONGQIANG LIU, QI WANG* （通讯作者） and MING HONG*， Exploring the active mechanism of berberine against HCC by systematic pharmacology and experimental validation，MOLECULAR MEDICINE REPORTS August 30, 2019， DOI: 10.3892/mmr.2019.10698

14. Li J, Gu Y, An H, Zhou Z, Zheng D, Wang Z, Wen Z, Shen H*, Wang Q*（王奇，通讯作者）,Wang H*, Cerebrospinal fluid light and heavy neurofilament level increased in anti-N-methyl-d-aspartate receptor encephalitis，Brain Behav，July 2019,DOI:10.1002/brb3.1354

15. Ming Hong, Honglian Shi, Ning Wang, Hor-Yue Tan, Qi Wang*（王奇，通讯作者）, and Yibin Feng *. Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network, Front Pharmacol, 2019 Jun 26. doi: 10.3389/fphar.2019.00696.

16. Xu YJ, Mei Y, Shi XQ, Zhang YF, Wang XY, Guan L, Wang Q*（王奇，通讯作者）, Pan HF*. Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction, Brain Res, 2019 Sep 15;1719:113-123. doi: 10.1016/j.brainres.2019.05.037. Epub 2019 May 28.

17. Ling-Feng Zeng, Wei-Yi Yang, Gui-Hong Liang, Ming-Hui Luo, Ye Cao, Hong-Yun Chen, Jian-Ke Pan, He-Tao Huang, Yan-Hong Han, Di Zhao, Jiong-Tong Lin, Sen-Rong Hou, Ai-Hua Ou, Zi-Tong Guan, Qi Wang⁎（王奇，通讯作者）, Jun Liu⁎， Can increasing the prevalence of vegetable-based diets lower the risk of osteoporosis in postmenopausal subjects? A systematic review with meta analysis of the literature，Complementary Therapies in Medicine， 2019，42：302-311

18. Sha Xiong,Wei Liu,Yile Zhou, Yousheng Mo, Yao Liu, Xiaojia Chen, Huafeng Pan, Dongsheng Yuan, Qi Wang*（王奇，通讯作者）, Tongkai Chen*.Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation, May 2019, Asian Journal of Pharmaceutical Sciences, DOI: 10.1016/j.ajps.2019.04.003

19. Xu YM, Wang XC, Xu TT, Li HY, Hei SY, Luo NC, Wang H, Zhao W, Fang SH, Chen YB, Guan L, Fang YQ, Zhang SJ*, Wang Q*（王奇，通讯作者）, Liang WX*. Kai Xin San ameliorates scopolamine-induced cognitive dysfunction, Neural Regen Res, 2019 May, doi: 10.4103/1673-5374.249227.

20. Yi-Jie Wang, Xin-Yue Wang, Xu-Yi Hao, Yong-Ming Yan, Ming Hong, Su-Fen Wei, 1 Yi-Le Zhou, 1Qi Wang*（王奇，通讯作者）, Yong-Xian Cheng*, and Yong-Qiang Liu*.Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway, Oxid Med Cell Longev, 2019 Apr 3. doi: 10.1155/2019/9421037.

21. Qu Z, Zheng N, Wei Y, Chen Y, Zhang Y, Zhang M, Chang H, Liu J, Ai H, Geng X*, Wang Q*（王奇，通讯作者），Yin L* ，Effect of cornel iridoid glycoside on microglia activation through suppression of the JAK/STAT signalling pathway, J Neuroimmunol, 2019 May, doi: 10.1016/j.jneuroim.2019.01.014. Epub 2019 Mar 4

2018年

1.Haobin Cai, Yunxia Luo, Xin Yan, Peng Ding, Yujie Huang, Shuhuan Fang, Rong Zhang, Yunbo Chen, Zhouke Guo, Jiansong Fang*, Qi Wang（王奇，通讯作者）*, Jun Xu*. The Mechanisms of Bushen-Yizhi Formula as a Therapeutic Agent against Alzheimer’s Disease, Scientific Reports, December 2018,DOI:10.1038/s41598-018-21468-w

2.Ling-Feng Zeng, Wei-Yi Yang, Gui-Hong Liang , Ye Cao , Jiong-Tong Lin, Zi-Tong Guan, Jun Liu*, Qi Wang（王奇，通讯作者）*. Can increasing the prevalence of vegetable-based diets lower the risk of osteoporosis in postmenopausal subjects? A systematic review with meta-analysis of the literature, Complementary Therapies in Medicine, November 2018, DOI: 10.1016/j.ctim.2018.11.026

3. Xu YM, Wang XC, Zhang SJ, Xu TT, Li HY, Hei SY, Wen ZH, Ma YZ*, Wang Q（王奇，通讯作者）*, Liang WX*. Role of Xingnaojing combined with naloxone in treating intracerebral haemorrhage:A systematic review and meta-analysis of randomized controlled trials, Medicine (Baltimore), October 2018, Doi: 10.1097/MD.0000000000012967

4.Jun Wu,Hailun Li,Xinyue Wang, Xiaolei Zhang,Weiping Liu,Yumei Wang,Yongbin Zhang, Huafeng Pan, Qi Wang（王奇，通讯作者）*,Yun Han*. Effect of polysaccharide from Undaria pinnatifida on proliferation, migration and apoptosis of breast cancer cell MCF7, International Journal of Biological Macromolecules, October 2018,DOI：10.1016/j.ijbiomac

5. Luo YX, Wang XY, Huang YJ, Fang SH, Wu J, Zhang YB, Xiong TQ, Yang C, Shen JG, Sang CL, Wang Q（王奇，通讯作者）*, Fang JS*. Systems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury, Chinese Journal of Natural Medicines, October 2018, DOI: 10.1016/S1875-5364(18)30115-8

6. Wang N, Liu W, Zheng Y, Wang S, Yang B, Li M, Song J, Zhang F, Zhang X, Wang Q（王奇，通讯作者）*, Wang Z*. CXCL1 derived from tumor- associated macrophages promotes breast cancer metastasis viaactivating NF-κB/SOX4 signaling, Cell Death&Disease, September 2018, DOI: 10.1038/s41419-018-0876-3

7. Mo Y, Xu E, Wei R, Le B, Song L, Li D, Chen Y, Ji X, Fang S, Shen J, Yang C*, Wang Q （王奇，通讯作者）*.Bushen-Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 InflammasomeActivation in a Mouse Model of Parkinson's Disease, Evidence-based Complementary and Alternative Medicine, August 2018, DOI: 10.1155/2018/3571604

8. Long Fan, Ruifeng Chen,Leng Li,Ziyao Liang,Xuhua Yu,Kai Huang, Shuomiao Yin,Lei Wu,Yuanbin Chen,Yinji Xu,Qi Wang（王奇，通讯作者）*, Lin Lin*. Protective Effect of Jianpiyifei II Granule against Chronic Obstructive Pulmonary Disease via NF- κ B Signaling Pathway, Evidence-based Complementary and Alternative Medicine, August 2018, DOI: 10.1155/2018/4265790

9. Xu YJ, Mei Y, Qu ZL, Zhang SJ, Zhao W, Fang JS, Wu J, Yang C, Liu SJ, Fang YQ, Wang Q（王奇，通讯作者）*, Zhang YB*. Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction, BioMed Research International , July 2018, DOI: 10.1155/2018/4606752

10. Wang XC, Xu YM, Li HY, Wu CY, Xu TT, Luo NC, Zhang SJ*, Wang Q（王奇，通讯作者）*, Quan SJ*.Jiao-TaiWan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice, BioMed Research International, June 2018, DOI:10.1155/2018/3538763

11. Huang M, Qi W, Fang S, Jiang P, Yang C, Mo Y, Dong C, Li Y, Zhong J, Cai W, Yang Z, Zhou T, Wang Q（王奇，通讯作者）*, Yang X*, Gao G*. Pigment Epithelium-Derived Factor Plays a Role in Alzheimer's Disease by Negatively Regulating Aβ42, Neurotherapeutics, 2018,15(3): 728–741.

12. Wu HF, Wang XY, Deng JF, Quan SJ, Wang Q（王奇，通讯作者）*, Li WR*. Pharmacokinetic Profiling of Butylidenephthalide and Alisol B in Danggui-Shaoyao-San in Rats, European Journal of Drug Metabolism and Pharmacokinetics, 2018,43(6):645-653.

13.Hong M*, Cai Z, Song L, Liu Y, Wang Q（王奇，通讯作者）*, Feng X*^. Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Diseasein Mice: A Biomedical Investigation Integrated with In Silico Assay, Evidence-based Complementary and Alternative Medicine, March 2018, Doi: 10.1155/2018/8384631

14.Hou XQ, Song HP, Chen YB, Cheng SY, Fang SH, Zhang JG*, Wang Q（王奇，通讯作者）*.Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice, Molecular Medicine Reports, 2018, 17(5): 6947-6960.

15. Ma XH, Duan WJ, Mo YS, Chen JL, Li S, Zhao W, Yang L, Mi SQ, Mao XL, Wang H*, Wang Q（王奇，通讯作者）*. Neuroprotective effect of paeoniflorin on okadaic acid- induced tau hyperphosphorylation via calpain/Akt/GSK-3β pathway in SH-SY5Y cells, Brain Research, 2018,1,1690:1-11.

16. Xu TT, Zhang Y, He JY, Luo D, Luo Y, Wang YJ, Liu W, Wu J, Zhao W, Fang J, Guan L, Huang S, Wang H, Lin L, Zhang SJ*, Wang Q（王奇，通讯作者）*. Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model, Cellular Physiology and Biochemistry, 2018,46(1):107-117

17. Dai YK, Li DY, Zhang YZ, Huang MX, Zhou YL, Ye JT, Wang Q（王奇，通讯作者）*, Hu L*. Efficacy and safety of Modified Tongxie Yaofang in diarrhea-predominant Irritable bowelsyndrome management:A meta-analysis of randomized, positive medicine-controlled trials, PLoS ONE, 2018,13(2):e0192319

2017年：

1.Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q（王奇，通讯作者）*, Xu H*.Intracellular trafficking of TREM2 is regulated by presenilin 1,Experimental and Molecular Medicine, 2017,49(12):e405.

2.Shi-Jie Zhang, Dan Luo，Lin Li, Rui-Rong Tan，Qing-Qing Xu，Jie Qin, Lei Zhu，Na-Chuan Luo, Ting-Ting Xu, Rong Zhang, Lei Yang*，Qi Wang（王奇，通讯作者）*，Ethyl Acetate Extract Components of Bushen-Yizhi Formula Provides Neuroprotection against Scopolamine-induced Cognitive Impairment，Scientific Reports， 2017,7(1):9824. DOI:10.1038/s41598-017-10437-4

3.Fang J*, Gao L, Ma H, Wu Q, Wu T, Wu J, Wang Q（王奇，通讯作者）*, Cheng F*. Quantitative and Systems Pharmacology 3. Network-Based Identification of New Targets for Natural Products Enables Potential Uses in Aging-Associated Disorders, Frontiers in Pharmacology, 2017,8:747.

4. Dong-Sheng Yuan, Yan-Ping Chen, Li-Li Tan, Shui-Qing Huang,Chang-Qing Li, Qi Wang（王奇，通讯作者）^*, Qing-Ping Zeng*. Artemisinin: A Panacea Eligible for Unrestrictive Use? Frontiers in Pharmacology, 2017, 8: 737.

5.Bonan Hou,Rui Liu, Zhen Qin,Dan Luo, Qi Wang（王奇，通讯作者）*, Shuiqing Huang*. Oral Chinese Herbal Medicine as an Adjuvant Treatment for Chemotherapy, or Radiotherapy, Induced Myelosuppression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Evidence-based Complementary and Alternative Medicine, August 2017,DOI: 10.1155/2017/3432750

6.Dai YK, Zhang YZ, Li DY, Ye JT, Zeng LF, Wang Q（王奇，通讯作者）*, Hu L*. The efficacy of Jianpi Yiqi therapy for chronic atrophic gastritis: A systematic review and meta-analysis, PLoS ONE, 2017 ,12(7):e0181906.

7．Qi Wang（王奇），Shui-Qing Huang，Chang-Qing LI，Qing Xu，Qing-Ping Zeng*，Akkermansia muciniphila May Determine Chondroitin Sulfate Ameliorating or Aggravating Osteoarthritis，Frontiers in Microbiology，October 2017，DOI: 10.3389/fmicb.2017.01955

8.Haobin Cai, Yijie Wang, Jiayang He, Tiantian Cai, Jun Wu, Jiansong Fang, Rong Zhang, Zhouke Guo, Li Guan, Qinkai Zhan, Li Lin, Yao Xiao, Huafeng Pan*，Qi Wang（王奇，通讯作者）*， Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice，Oncotarget，2017，

9.Shi-Jie Zhang, Ting-Ting Xu, Lin Li, Yu-Min Xu, Zi-Ling Qu, Xin-Chen Wang, Shui-Qing Huang, Yi Luo, Na-Chuan Luo, Ping Lu, Ya-Fei Shi, Xin Yang*，Qi Wang（王奇，通讯作者）*，Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice，Oncotarget, 2017，

10.Jiang He, Tao Liao, Guo-Xin Zhong, Ji-Da Zhang, Yan-Ping Chen, Qi Wang（王奇，通讯作者）*，Qing-Ping Zeng*，Alzheimer’s Disease-like Early-phase Brain Pathogenesis: Self-curing Amelioration of Neurodegeneration from Pro-inflammatory ‘Wounding’ to Anti-inflammatory ‘Healing’， Current Alzheimer Research, 2017, 14, 1-13

11.Bonan Hou，Rui Liu，Zhen Qin，Dan Luo，Qi Wang（王奇，通讯作者）*，Shuiqing Huang*，Oral Chinese Herbal Medicine as an Adjuvant Treatment for Chemotherapy, or Radiotherapy, Induced Myelosuppression:A Systematic Review and Meta-Analysis of Randomized Controlled Trials，Evidence-Based Complementary and Alternative Medicine，2017，doi.org/10.1155/2017/3432750

12.Chuipu Cai，Qihui Wu，Yunxia Luo，Huili Ma，Jiangang Shen，Yongbin Zhang，Lei Yang，Yunbo Chen，Zehuai Wen*，Qi Wang（王奇，通讯作者）*，In silico prediction of ROCK II inhibitors by different classification approaches，Mol Divers，2017，DOI 10.1007/s11030-017-9772-5

13.Wu J, Gao W, Song Z, Xiong Q, Xu Y, Han Y, Yuan J, Zhang R, Cheng Y, Fang J, Li W, Wang Q（王奇，通讯作者）*. Anticancer activity of polysaccharide from Glehnia littoralis on human lung cancer cell line A549，Int J Biol Macromol. 2017，doi: 10.1016/j.ijbiomac.2017.08.033

14.Dai R, Zhang S, Duan W, Wei R, Chen H, Cai W, Yang L*, Wang Q（王奇，通讯作者）*，Enhanced Autophagy Contributes to Protective Effects of GM1 Ganglioside Against Aβ1-42-Induced Neurotoxicity and Cognitive Deficits，Neurochem Res. 2017，42(8):2417-2426

15.Jiansong Fang，Ling Wang , Yecheng Li，Wenwen Lian，Xiaocong Pang，Hong Wang，Dongsheng Yuan，Qi Wang（王奇，通讯作者）*，Ai-Lin Liu*，Guan-Hua Du*，AlzhCPI:A knowledge base for predicting chemical-protein interactions towards Alzheimer’s disease，PLoS One. 2017 May 25;12(5):e0178347. doi: 10.1371/journal.pone.0178347

16.Yifan Zhang，Linlin Yin*，Na Zheng，Li Zhang，Jianghong Liu，Weixiong Liang，Qi Wang（王奇，通讯作者）*，Icariin enhances remyelination process after acute demyelination induced by cuprizone exposure，Brain Research Bulletin，2017，130：180~187

17.Jiansong Fang，Ling Wang，Tian Wu，Cong Yang，Li Gao，HaoBin Cai，Junhui Liu，Shuhuang Fang，Yunbo Chen，Wen Tan*，Qi Wang（王奇，通讯作者）*，Network Pharmacology-based Study on the Mechanism of Action for Herbal Medicines inAlzheimer Treatment，Journal of Ethnopharmacology，2017，196：281~292

18.Ling-Feng Zeng，Ye Cao，Wei-Xiong Liang，Wen-Hu Bao，Jian-Ke Pan，Qi Wang（王奇，通讯作者）*，Jun Liu*，Hao-Dong Liang，Hui Xie，Yan-Ting Chai，Zi-Tong Guan，Qian Cao，Xiao-Yan L，Lei Yang，Wei-Hua Xu，Sui-Qing Mi，Ning-Sheng Wang，An exploration of the role of a fish-oriented diet in cognitive decline: a systematic review of the literature，Oncotarget, 2017，39877-39895

19. Zeng, Ling-Feng，Cao, Ye，Wang, Lu，Dai, Yun-Kai，Hu, Ling*，Wang, Qi*（王奇），Zhu, Li-Ting，Bao, Wen-Hu，Zou, Yuan-Ping，Chen, Yun-Bo，Xu, Wei-Hua，Liang, Wei-Xiong，Wang, Ning-Sheng，Role of Medicinal Plants for Liver-Qi Regulation Adjuvant Therapy in Post-stroke Depression: A Systematic Review of Literature，PHYTOTHERAPY RESEARCH，2017.1，31(1)：40~52

2016年

1.Li, Chang-Qing，Zheng, Qing，Wang Qi（王奇，通讯作者）*，Zeng, Qing-Ping*，Biotic/Abiotic Stress-Driven Alzheimer's Disease，Frontiers in Cellular Neuroscience，2016，10

2.Hao-Bin Cai，Qi Wang（王奇，通讯作者）*，Guang-Liang Wu，Cen-Han Huang*，Zhong-Shi Huang，Yun-Bo Chen，Effect of Zhuang Jing Decoction on Learning and Memory Ability in Aging Rats，Rejuvenation Research，2016，19（4）：1~6

3.Lingfeng Zeng，Weixiong Liang，Jianke Pan，Ye Cao，Jun Liu*，Qi Wang（王奇，通讯作者）*，Lu Wang，Yuanping Zou，Kezhu Wang，Lingshuo Kong，Hui Xie，Weihua Xu，Weirong Li，Wei Zhao，Suiqing Mi，Yunbo Chen，Shuyi Cheng，Xiaoyan Li，Qian Cao，Xing Zeng，Ningsheng Wang，Do Chinese Researchers Conduct Ethical Research and Use Ethics Committee Review in Clinical Trials of Anti-Dementia Drugs? AnAnalysis of Biomedical Publications Originating from China，Journal of Alzheimers Disease，2016，52（3）

4.Qu, Zhao，Zheng, Na，Zhang, Yifan，Zhang, Li，Liu, Jianghong，Wang Qi（王奇，通讯作者）*，Yin, Linlin*，Preventing the BDNF and NGF loss involved in the effects of cornel iridoid glycoside on attenuation of experimental autoimmune encephalomyelitis in mice，Neurological Research，2016，38（9）：831~837

5. Wang, Ningsheng，Zeng, Lingfeng，Zeng, Xing，Liu, Jun，Liang, Weixiong*，Wang Qi（王奇，通讯作者）*，A Population Perspective on Ethical Compliance with Drug Trial Standards of Practice，Journal of Alzheimer's Disease，2016，52（3）：829~830

6.Yang, Cong，Li, Xiaoguang，Mo, Yousheng，Liu, Sijun，Zhao, Luguang，Ma, Xiaohui，Fang, Zhigang，Chen, Junli，Chen, Yunbo，Yu, Xuhua，Fang, Shuhuan，Zhang, Yongbin，Xian, Shaoxiang*，Wang, Qi（王奇，通讯作者）*，beta-Asarone Mitigates Amyloidosis and Downregulates RAGE in a Transgenic Mouse Model of Alzheimer's Disease，Cellular and Molecular Neurobiology，2016，36（1）：121~130

7.LUO Yunxia，WANG Qi （王奇，通讯作者）*，ZHANG Yongbing*，A systems pharmacology approach to decipher the mechanism of danggui-shaoyao-san decoction for the treatment of neurodegenerative diseases，Journal of Ethnopharmacology，2016，178：66~81

8. Zeng, Ling-Feng，Lang, Wei-Xiong，Liu, Jia-Ci，Chen, Xiao-Yan，Du, Wen-Yi，Li, Zi-Ping*，Wang Qi（王奇，通讯作者）*，Cao, Ye，Wang, Lu，Meng, Chang-Rong，Wang, Ke-Zhu，Wang, Ning-Sheng，Is adjunctive treatment with medication of liver-soothing-oriented method beneficial for depression after cerebrovascular accident? A PRISMA-compliant meta-analysis，Medicine，2016，95（44）

9. Luguang Zhao，Dan He，Mengmeng Jiao，Lingshuo Kong，Chunkui Shao，Junli Chen，Zhigang Fang，Xiaohui Ma，Huifang Chen，Lin Li，Si Luo，Na Zheng，Yunbo Chen，Qi Wang（王奇，通讯作者）*，Shuhuan Fang*，Overexpression of Histone Deacetylase and Amyloid Precursor Protein in Hepatocellular Carcinoma.，Technology in Cancer Research & Treatment，2016，16（1）：1~9

10. Liu, Si-jun，Yang, Cong，Zhang, Yue，Su, Ru-yu，Chen, Jun-li，Jiao, Meng-meng，Chen, Hui-fang，Zheng, Na，Luo, Si，Chen, Yun-bo，Quan, Shi-jian*，Wang Qi（王奇，通讯作者）*，Neuroprotective effect of beta-asarone against Alzheimer's disease: regulation of synaptic plasticity by increased expression of SYP and GluR1，Drug Design, Development and Therapy，2016，10：1461~1469

2015年

1. Zhang, Shi-Jie，Li, Yi-Fang，Wang, Guo-En，Tan, Rui-Rong，Tsoi, Bun，Mao, Gao-Wei，Zhai, Yu-Jia，Cao, Ling-Fang，Chen, Min，Kurihara, Hiroshi，Wang, Qi（王奇，通讯作者）*，He, Rong-Rong*，Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway，Food & Function，2015，6（8）：2578~2587

2. Tan, Rui-Rong，Zhang, Shi-Jie，Li, Yi-Fang，Tsoi, Bun，Huang, Wen-Shan，Yao, Nan，Hong, Mo，Zhai, Yu-Jia，Mao, Zhong-Fu，Tang, Lu-Ping，Kurihara, Hiroshi，Wang, Qi（王奇，通讯作者）*，He, Rong-Rong*，Proanthocyanidins Prevent High Glucose-Induced Eye Malformation by Restoring Pax6 Expression in Chick Embryo，Nutrients，2015，7（8）：6567~6581

3. Zhi, Hui，Zheng, Junxia，Chang, Yiqun，Li, Qingguo，Liao, Guochao，Wang, Qi（王奇，通讯作者）*，Sun, Pinghua*，QSAR studies on triazole derivatives as sglt inhibitors via CoMFA and CoMSIA，Journal of Molecular Structure，2015，1098：199~205

4. He, Wen-Qing，Lv, Wei-Sheng，Zhang, Yu，Qu, Zhao，Wei, Ren-Rong，Zhang, Lei，Liu, Chang-Hui，Zhou, Xin-Xin，Li, Wei-Rong，Huang, Xiao-Tao*，Wang, Qi（王奇，通讯作者）*，Study on Pharmacokinetics of Three Preparations from Levistolide A by LC-MS-MS，Journal of Chromatographic Science，2015，53（8）：1265~1273

5. Zeng, Ling-feng，Wang, Ning-sheng*，Wang, Qi（王奇，通讯作者）*，Zou, Yuan-ping，Liang, Zhao-hui，Kong, Ling-shuo，Wu, Hai-tao，Liao, Nan-ying，Liang, Xiao-wen，Mo, You-sheng，Oral Chinese herbal medicine for kidney nourishment in Alzheimer's disease: A systematic review of the effect on MMSE index measures and safety，Complementary Therapies in Medicine，2015，23（2）：283~297

6. Chang, Xiang，Rong, Cuiping，Chen, Yunbo，Yang, Cong，Hu, Qian，Mo, Yousheng，Zhang, Chunxia，Gu, Xiaoqiong，Zhang, Lei，He, Wenqing，Cheng, Shuyi，Hou, Xueqin，Su, Ruyu，Liu, Sijun，Dun, Wenjun，Wang, Qi（王奇，通讯作者）*，Fang, Shuhuan*，(-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression，Experimental Cell Research，2015，334（1）：136~145

7. Ji, Shu-Shen，Dong, Hong-Ju，Zhou, Xin-Xin，Liu, Ya-Min，Zhang, Feng-Xue，Wang, Qi（王奇，通讯作者）*，Huang, Xin-An*，A Structural Hierarchy Matching Approach for Molecular Similarity/Substructure Searching，Molecules，2015，20（5）：8791~8799

8. Hu, Qian，Chang, Xiang，Yan, Rong，Rong, Cuiping，Yang, Cong，Cheng, Shuyi，Gu, Xiaoqiong，Yao, Herui，Hou, Xueqin，Mo, Yousheng，Zhao, Luguang，Chen, Yunbo，Dinlin, Xiaoxiao，Wang, Qi（王奇，通讯作者）*，Fang, Shuhuan*，(-)-Epigallocatechin-3-gallate induces cancer cell apoptosis via acetylation of amyloid precursor protein，Medical Oncology，2015，32（1）

9. Lingfeng Zeng，Yuanping Zou，Lingshuo Kong，Ningsheng Wang*，Qi Wang（王奇，通讯作者）*，Lu Wang，Ye Cao，Kezhu Wang，Yunbo Chen，Suiqing Mi，Wei Zhao，Haitao Wu，Shuyi Cheng，Weihua Xu，Weixiong Liang，Can Chinese Herbal Medicine Adjunctive Therapy Improve Outcomes of Senile Vascular Dementia? Systematic Reviewwith Meta-analysis of Clinical Trials，PHYTOTHERAPY RESEARCH，2015，29（12）：1843~1857

10. Hou, Xue-Qin，Zhang, Lei，Yang, Cong，Rong, Cui-Ping，He, Wen-Qing，Zhang, Chun-Xia，Li, Shi，Su, Ru-Yu，Chang, Xiang，Qin, Ji-Huan，Chen, Yun-Bo，Xian, Shao-Xiang*，Wang, Qi（王奇，通讯作者）*，Alleviating Effects of Bushen-Yizhi Formula on Ibotenic Acid-Induced Cholinergic Impairments in Rat，Rejuvenation Research，2015，18（2）：111~127

2014年

1. Chen, Yunbo，Wei, Gang，Nie, Hui，Lin, Yaping，Tian, Huijuan，Liu, Yu，Yu, Xuhua，Cheng, Shuyi，Yan, Rong，Wang, Qi（王奇，通讯作者）*，Liu, Donghui，Deng, Weiye，Lai, Yingtao，Zhou, Jianhong，Zhang, Saixia，Lin, Weiwei，Chen, Dongfeng*， beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice，Brain Research，2014，1552：41~54

2. Cai, Qingyan(#)，Wei, Jingjing，Zhao, Wei，Shi, Si，Zhang, Yu，Wei, Renrong，Zhang, Yue，Li, Weirong*，Wang, Qi（王奇，通讯作者）*，Toxicity of Evodiae fructus on Rat Liver Mitochondria: The Role of Oxidative Stress and Mitochondrial Permeability Transition，Molecules，2014，19（12）：21168~21182

3. Hou, Xue-Qin，Wu, Dian-Wei，Zhang, Chun-Xia，Yan, Rong，Yang, Cong，Rong, Cui-Ping，Zhang, Lei，Chang, Xiang，Su, Ru-Yu，Zhang, Shi-Jie，He, Wen-Qing，Qu, Zhao，Li, Shi，Su, Zi-Ren，Chen, Yun-Bo，Wang, Qi（王奇，通讯作者）*，Fang, Shu-Huan*，Bushen-Yizhi formula ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in scopolamine-induced senescence in mice，International Journal of Molecular Medicine，2014，34（2）：429~439

4. Zhang, Lei，Yan, Rong，Su, Ruyu，Yang, Cong，Liu, Sijun，Yu, Xuhua，Chang, Xiang，Zhang, Shijie，Liu, Changhui，Xu, Meili，Zeng, Wu，Chen, Yunbo*，Wang, Qi（王奇，通讯作者）*，Bioavailability enhancement of osthole after oral administration of Bushen Yizhi prescription extract to rats followed by Cnidium monnieri (L.) Cusson fruits extract in comparison to pure osthole at different doses，Journal of Ethnopharmacology，2014，152（2）：266~271

5. Hou, Xue-Qin，Yan, Rong，Yang, Cong，Zhang, Lei，Su, Ru-Yu，Liu, Si-Jun，Zhang, Shi-Jie，He, Wen-Qing，Fang, Shu-Huan，Cheng, Shu-Yi，Su, Zi-Ren，Chen, Yun-Bo*，Wang, Qi（王奇，通讯作者）*，A novel assay for high-throughput screening of anti-Alzheimer's disease drugs to determine their efficacy by real-time monitoring of changes in PC12 cell proliferation，International Journal of Molecular Medicine，2014，33（3）：543~549

主要中文论文：

1. 黄伟，李涵，李本岳，张洋，关莉*，王奇*，川芎嗪对t-BHP致PC12细胞损伤的保护及机制，中国实验方剂学杂志，2019，（25）：67-72

2. 罗纳川，綦向军，陈国铭，陈腾宇，吴淼，田燕华，方彩珊，梁妙珍，卢以茜，王奇*，治疗便秘方剂中辛味药物的应用规律，中医杂志，2019，60（2）：163-168

3.许玉珉，章时杰，王馨晨，许婷婷，詹钦凯，梁伟雄，王奇*，补肾益智方对Aβ25-35致阿尔茨海默病小鼠空间学习记忆及细胞凋亡机制的研究，中药药理与临床，2018，34(1)：127-130

4.陈惠芳，莫友胜，杨从，侯伯南，王奇*，槲皮素对鹅膏蕈氨酸致痴呆大鼠模型海马神经元的保护作用及机制，中药新药与临床药理，2018，29（5）：552-556

5.黄燕辉，赵路光，孔令朔，王奇*，基于转基因秀丽隐杆线虫模型的抗阿尔茨海默病中药成分筛选思路，中药新药与临床药理，2017，28（5）：699-702

6.张越，陈惠芳，郑娜，李晓光，许庆庆，祝晨蔯，王奇*，女贞苷对Aβ42诱导的神经细胞凋亡及相关蛋白NF-κB、Bcl-2变化的影响，中药新药与临床药理，2016，（02）：215~219

7. 张越，李琳，李晓光，陈惠芳，罗思，陈云波，祝晨蔯，王奇*，女贞苷对Aβ1-42损伤SH-SY5Y细胞的保护作用及其机制，暨南大学学报，2016.1.01，（01）：1~6

8. 刘四军，陈惠芳，张一帆，王莹莹，陈云波，王奇*，β-细辛醚对阿尔茨海默病细胞模型的作用及对神经元突触功能可塑性的影响，中药新药与临床药理，2016，（01）：54~57

9. 苏如玉，张磊，张玉，闫蓉，侯雪芹，屈赵，杨从，陈云波，王奇*，从药物代谢动力学角度探讨中药复方有效性的思路与方法，中国中西医结合杂志，2016，（01）：111~115

10. 代汝伟，章时杰，蔡伟彬，陈惠芳，郑娜，许庆庆，张一帆，王奇*，原儿茶酸对β淀粉样蛋白_(1-42)诱导PC12细胞毒性的保护作用及机制，广州中医药大学学报，2016.1.20，（01）：66~70

11. 侯雪芹，张磊，林雅萍，田会娟，张春霞，刘玉，杨从，王奇*，陈云波，程淑意，方淑环，4种阿尔茨海默病动物模型行为学改变及凋亡机制的比较，中国老年学杂志，2015.6.25，（12）：3185~3187

12.常翔，方淑环，张玉，闫蓉，屈赵，侯雪芹，苏如玉，张磊，杨从，王奇*，新生小鼠海马神经元培养及形态学观察的优化方法，重庆医学，2014.8.10，（22）：2910~2912

13. 侯雪芹，陈云波，程淑意，段文君，方淑环，王奇*，补肾益智提取物对AD小鼠空间学习记忆及氧化应激-凋亡相关机制的研究，中华中医药杂志，2015.5.1，（05）：1640~1643

14. 侯雪芹，魏仁荣，张玉，高文斌，闫蓉，王奇*，基于文献分析的“中药复方干预痴呆动物模型”研究规律及其发展现状，中国实验方剂学杂志，2015.2.01，（03）：201~204

15. 闫蓉，常翔，杨从，苏如玉，侯雪芹，张磊，张春霞，方淑环，陈云波，王奇*，阿尔兹海默病β淀粉样蛋白形成和沉积的发病机制及中医药干预的可能途径，中药新药与临床药理，2013.01.01，（06）：629~632