科技创新中心

Science and Technology Innovation Center，Guangzhou University of Chinese Medicine

杏林青年人才

姓名：周经纬

专业：药物化学

研究方向：计算机辅助药物设计

教育背景及工作经历：

2012年-2017年：中山大学，药物化学，博士

2018年-至今：广州中医药大学，临床药理研究所，研究员

主要承担项目：

国家自然科学基金，基于QM/MM方法对中药提取物中的DXR抑制剂的优化，81803436，2019.01-2021.12，21万，本人主持

代表性论文：列第一（含共一）、通讯（含共同通讯）作者文章，注明影响因子(本人名字请加粗、下划线显示)

1. Wu, Q., Ke, H., Li, D., Wang, Q., Fang, J., &Zhou, J.* Recent Progress in Machine Learning-based Prediction of Peptide Activity for Drug Discovery.Curr. Top. Med. Chem.2019, 19,4-16. (IF = 3.442)

2. Hu, M.^#,Zhou, J.^#, Luo, W., Chen, S., Huang, Z., Wu, R., & Tan, J. Development of a Smart Fluorescent Sensor That Specifically Recognizes the c-MYC G-Quadruplex.Anal. Chem.2019, 91(3), 2480-2487. (IF = 6.35)

3.Zhou, J., Huang, Y., Cheng, C., Wang, K., & Wu, R. Intrinsic Dynamics of the Binding Rail and Its Allosteric Effect in the Class I Histone Deacetylases.J. Chem. Inf. Model.2017,57(9), 2309-2320.(IF = 3.760)

4.Zhou, J., Yang, Z., Zhang, F., Luo, H., Li, Min., & Wu, R. A Salt Bridge Turns Off the Foot-Pocket in Class-II HDACs.Phys. Chem. Chem. Phys.2016,18(31), 21246-21250.(IF = 4.493)

5.Zhou, J., Wang, X., Kuang, M., Wang, L., Luo, H., Mo, Y., & Wu, R. Protonation-Triggered Carbon-Chain-Chain Elongation in Geranyl Pyrophosphate Synthase (GPPS).ACS Catal.2015,5(7), 4466-4478.(IF = 10.614)

6.Zhou, J., Wu, R., Wang, B., Cao, Z., Yan, H., & Mo, Y. Proton-Shuttle-Assisted Heterolytic Carbon-Carbon Bond Cleavage and Formation.ACS Catal.2015,5(5), 2805-2813.(IF = 10.614)

7.Zhou, J., Wu, R., & Luo, H. Inhibition Mechanism of SAHA in HDAC: A Revisit.Phys. Chem. Chem. Phys.2015,17(44), 29483-29488.(IF = 4.493)

8.Zhou, J., Li, M., Chen, N., Wang, S., Luo, H., Zhang, Y., & Wu, R. Computational Design of a Time-Dependent Histone Deacetylase 2 Selective Inhibitor.ACS Chem. Biol.2015,10(3), 687-692.(IF = 5.331)

9. Liu, Z.^#,Zhou, J.^#, Wu, R., & Xu, J. Mechanism of Assembling Isoprenoid Building Blocks 1. Elucidation of the Structural Motifs for Substrate Binding in Geranyl Pyrophosphate Synthase.J. Chem. Theory Comput.2014,10(11), 5057-5067.(IF = 5.245)

10.Zhou, J., Xie, H., Liu, Z., Luo, H., & Wu, R. (2014). Structure−Function Analysis of the Conserved Tyrosine and Diverse π-Stacking among Class I Histone Deacetylases: A QM (DFT)/MM MD Study.J. Chem. Inf. Model.2014,54(11), 3162-3171.(IF = 3.760)