科技创新中心
Science and Technology Innovation Center，Guangzhou University of Chinese Medicine
杏林后备人才
姓名：刘永强
专业：中药药理
研究方向：中药抗肿瘤分子机理研究
教育背景及工作经历：
2017.7-至今，副研究员，广州中医药大学临床药理研究所。
2014.11-2017.6，博士后，美国福克斯蔡司癌症研究中心。
2009.10-2013.12，博士，生物化学与分子生物学专业，中国科学院动物研究所膜生物学国家重点实验室。
2007.7-2009.9,硕士，生物化学与分子生物学专业，中国科学院广州生物医药与健康研究院。
主要承担项目：
1.国家自然科学基金青年项目，小胶质细胞通过分泌IL-1β招募星形胶质细胞进而促进髓母细胞瘤发生的分子机理研究，81802776，2019.1-2021.12，21万元，负责人：刘永强。
2.高水平大学建设杏林人才科研配套经费，2017.7-2020.7，40万，负责人：刘永强。
代表性论文：
1.Yi-Jie Wang, Xin-Yue Wang,Xu-Yi Hao, Yong-Ming Yan,Ming Hong, Su-Fen Wei, Yi-Le Zhou, Qi Wang,Yong-Xian Cheng,Yong-Qiang Liu.Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway. OxidativeMedicine andCellularLongevity, 2019.vol. 2019, Article ID 9421037, 2019. (IF=4.87)
2.Yi-le Zhou, Yong-ming Yan, Si-yi Li, Dan-hua He, Sha Xiong, Su-fen Wei, Wei Liu, Ling Hu, Qi Wang, Hua-feng Pan, Yong-xian Cheng,Yong-qiang Liu.6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Acta Pharmacologica Sinica.2019,0:1–12.(IF=4.01)
3.Yongqiang Liu, Larra Yuelling,Yuan Wan, Fang Du, Renata E. Gordon,Jenny A. O'Brien, Jessica M.Y. Ng, Shannon Robins, Eric H. Lee, Hailong Liu,Tom Curran,Zengjie Yang. Astrocytes promote medulloblastoma progression through hedgehog secretion.Cancer Research. 2017,77(23):6692-6703. (IF=8.38)
4.Wenfeng Lu#,Yongqiang Liu#,Haikuo Ma, Jiyue Zheng, Sheng Tian, Zhijian Sun, LusongLuo, Jiajun Li, Hongjian Zhang, Zeng-Jie Yang, Xiaohu Zhang. Design, Synthesis, andStructure-Activity-Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity. ACS Chemical Neuroscience.2017,8(9):1980-1994. (co-first auther, IF=3.86)
5.Yong-Qiang Liu, Xiao-Lu Wang, Xin Cheng, Yong-Zhi Lu, Gui-Zhen Wang, Xin-Chun Li, Jian Zhang,Zhe-Sheng Wen,Zhi-Liang Huang, Qin-Lei Gao, Li-Na Yang, Yong-Xian Cheng, Sheng-Ce Tao,Jinsong Liu, and Guang-Biao Zhou. Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors.Oncotarget.2015, 6(33): 34953-67.
6.Gui-Zhen Wang#,Yong-Qiang Liu#,Xin Cheng,Guang-Biao Zhou. Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents. Cancer Science. 2015, 106(7): 902–908. (co-first author, IF=4.75)
7.Yong-Qiang Liu, Xin Cheng, Liang-Xia Guo, Chan Mao, Yi-Jie Chen, Hai-Xia Liu, Qi-Cai Xiao, Sheng Jiang, Zhu-Jun Yao, Guang-Biao Zhou. Identification of an Annonaceous Acetogenin Mimetic, AA005, as an AMPK Activator and Autophagy Inducer in Colon Cancer Cells. PLoS One, 2012, 7(10): e47049. (IF=2.78)
8.Qicai Xiao#,Yongqiang Liu#,Yatao Qiu, Guangbiao Zhou, Chan Mao, Zheng Li, Zhu-Jun Yao, Sheng Jiang. Poten antitumor mimetics of Annonaceous Acetogenins Embedded with an Aromatic Moiety in the Left Hydrocarbon Chain Part.JournalofMedicinalChemistry. 2011, 54(2):525–533. (co-first author,IF=6.05)
