科技创新中心
中医药防治脾胃病和神经肌肉病研究团队
研究方向：中医药防治脾胃病和神经肌肉病的临床与基础研究
课题组组长：宋雅芳研究员
教育背景及工作经历：
2002-2005年：上海中医药大学，中医内科学，博士
2005-2008年：广州中医药大学，中医学博士后流动站，博士后
2008-至今：广州中医药大学，脾胃研究所，研究员
2014-2015年：美国马里兰大学访问学者
课题组成员：潘华峰教授、陈冠林研究员、林传权副研究员
课题组简介：本团队以脾胃病及神经肌肉病等中医优势病种为主攻方向，以提高临床疗效为导向，突出中医药特色优势，系统探讨中医药在疾病发生、发展中的作用机制，发现其潜在治疗靶点，为脾胃病及神经肌肉病提供更高效的诊疗方案。
主要承担项目：
1.国家自然科学基金，基于PGC-1α信号转导探讨健脾益气法对重症肌无力大鼠骨骼肌线粒体调控机制，81473568，2015/01-2018/12，70万元，宋雅芳主持。
2.国家自然科学基金，从“PKA/NLRP3炎症小体-巨噬细胞焦亡”探讨健脾化瘀解毒方防治胃癌前病变的分子机制研究，81973816，2020/01-2023/12，56万元，潘华峰主持。
3.国家自然科学基金，健脾化瘀解毒方调控mTOR/HIF-1α/SIRT6通路介导胃癌前病变有氧糖酵解的分子机制研究，81673946，2017/01-2020/12，57万元，潘华峰主持
4.国家自然科学基金，胃痞消逆转TGF-β/Smads通路介导胃癌前病变上皮-间质转化分子机制研究，81473620，2015/01-2018/12，76万，潘华峰主持。
5.广州市科技计划项目，基于大数据分析的胃癌前病变中医精准医学治疗方案研究，201803010055，2018/04-2021/03，100万，潘华峰主持。
6.国家自然科学基金，基于生物质谱探讨唾液淀粉酶N-糖基化修饰在脾气虚证动态演变过程的变化特点，81973723，2020/01-2023/12，52万元，林传权主持.
7.国家自然科学基金，从AMY1基因拷贝数变异及GnT-I/II介导N-糖基化探讨脾气虚证唾液淀粉酶活性改变的机制，81403297，2015/01-2017/12，23万元，林传权主持。
代表性论文：
1.Jingwei Song, Xiaowen Lei, Wei Jiao, Yafang Song*, Weijing Chen, Jinqiu Li & Zhiwei Chen. Effect of Qiangji Jianli decoctionon mitochondrial respiratory chain activity and expression of mitochondrial fusion and fssion proteins in myasthenia gravis rats. Scientific Reports. 2018, 8(1): 8623.
2.Zhigang Lv,Yafang Song, Dongying Xue, Wenwei Zhang, Yang Cheng, Lieming Xu. Effect of Salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells. Journal of Ethnopharmacology.2010, 132(2):384-392.
3.Liangjun Yang, Wei Liu, Zhipeng Hu, Maoyi Yang, Jiali Li, Xiangzhen Fan, and Huafeng Pan*. A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action of the Wei Pi Xiao Decoction for the Treatment of Gastric Precancerous Lesions. Evidence-Based Complementary and Alternative Medicine.2019, 2019: 15.
4.Jinhao Zeng, Ran Yan, Huafeng Pan*, Fengming You, Tiantian Cai, Wei Liu, Chuan Zheng, Ziming Zhao, Daoyin Gong, Longhui Chen, Yi Zhang.Weipixiao attenuate early angiogenesis in rats with gastric precancerous lesions. BMC complementary and alternative medicine.2018,18(1):250.
5.LiuWei,PanHua-feng*, WangQi, ZhaoZi-ming.The application of transgenic and gene knockout mice in the study of gastric precancerous lesions.Pathology-Research and Practice.2018,214:1929-1939.
6.Cai Tiantian, Zhang Chengzhe, Zhao Ziming, Li Siyi, Cai Haobin, Chen Xiaodong, Cai Dake, Liu Wei, Yan Yan, Xie Kaifeng, Pan Huafeng*, Zeng Xiaohui.The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats. Biomed. Pharmacother.2018,104:291-299.
7.Zhang Chengzhe, Cai Tiantian, Zeng Xiaohui, Cai Dake, Chen Yuxing, Huang Xuejun, Gan Haining, Zhuo Juncheng, Zhao Ziming, Pan Huafeng*,Li Siyi.Astragaloside IV reverses MNNG-induced precancerous lesions of gastric carcinoma in rats: Regulation on glycolysis through miRNA-34a/LDHA pathway. Phytother Res.2018,32:1364-1372.
8.Zheng Zuoliang,Li Shengqing,ZhongYuping,ZhanRuoting,YanYan,PanHuafeng*, Yan Ping. UPLC-QTOF-MSidentification of the chemical constituents in rat plasma and urine after oral administration of rubia cordifoliaL. extract. Molecules. 2017. 22(8):1327.
9.Lin Chuan-Quan*, Wang Li-Hui, Yang Long, Qiu Xiang-Hong, Wang Dong-Xu, Liang Xue-Dan, Chen Long-Hui, Xie Hai-Mei, Wang Shuang-Shuang, Li Ru-Liu. Abnormalities in acute salivary biochemical characteristic responses to gustatory stimulation with citric acid in chronic non-atrophic gastritis. Journal of Gastroenterology and Hepatology, doi:10.1111/jgh.14587.
10.Wang Li-Hui, Lin Chuan-Quan*,Yang Long, Li Ru-Liu, Chen Long-Hui, Chen Wei-Wen. Gender differences in the saliva of young healthy subjects before and after citric acid stimulation. Clinica Chimica Acta, 2016, 460:142-145.
